Material Safety Data Sheet: Vitamin E Acetate

Identification

Product Name: Vitamin E Acetate
Synonyms: Tocopheryl acetate
Chemical Family: Tocopherol esters
Formula: C31H52O3
Molecular Weight: 472.75 g/mol
CAS Number: 7695-91-2
Intended Uses: Nutritional supplement, cosmetic ingredient, pharmaceutical applications
Supplier Contact: Customer Service, listed on accompanying documentation
Emergency Phone: Emergency protocols issued by company or local health and fire authorities

Hazard Identification

GHS Classification: Not classified as hazardous
Signal Word: None
Pictograms: No symbol required under GHS
Potential Health Effects: May cause mild skin or eye irritation in sensitive individuals, ingestion may cause gastrointestinal discomfort
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Target Organs: No evidence of systemic toxicity at normal exposure
Environmental Hazards: No significant environmental hazards known under recommended handling
Label Statements: Avoid prolonged contact with skin and eyes, handle in accordance with good hygiene

Composition / Information on Ingredients

Chemical Name: DL-α-Tocopheryl Acetate
Concentration: ≥98%
Impurities: Trace related tocopherol derivatives
Ingredient Classification: Single component substance, non-hazardous impurities at extremely low concentrations
Additives: None reported

First Aid Measures

Inhalation: Move exposed person to fresh air, monitor for respiratory irritation, seek medical guidance if symptoms persist
Skin Contact: Wash with soap and water, remove contaminated clothing, medical assistance rarely needed unless irritation develops
Eye Contact: Rinse gently with running water for 15 minutes, remove contact lenses, medical consultation if symptoms remain
Ingestion: Rinse mouth, drink water, obtain medical attention only if symptoms develop
Notes for Physician: Treat symptomatically, no specific antidote, supportive care based on clinical findings

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Media: Do not use water jet, may spread burning oil
Specific Hazards: Combustion produces acrid fumes, carbon oxides
Protective Equipment: Wear full protective gear and self-contained breathing apparatus
Special Procedures: Use caution, approach fire from upwind, cool containers exposed to flames
Explosion Data: Not susceptible to explosion under normal storage and handling

Accidental Release Measures

Personal Precautions: Wear gloves, goggles, avoid breathing vapor or mist
Environmental Precautions: Prevent runoff into sewers, drains, or watercourses
Spill Cleanup Methods: Absorb with inert material such as sand or earth, scoop into containers for disposal, ventilate area if large spill
Decontamination: Wash spill site with soap and water after cleanup
Waste Disposal: Dispose of in accordance with local and national regulations

Handling and Storage

Handling: Use with adequate ventilation, avoid skin and eye contact, practice standard hygiene, avoid ingestion
Storage Conditions: Store in tightly sealed container, cool and dry place, protect from light, avoid heat and direct sunlight
Storage Incompatibilities: Strong oxidizers, strong acids
Container Requirements: Keep container tightly closed, use original container when possible

Exposure Controls and Personal Protection

Exposure Limits: Not established by OSHA, ACGIH, NIOSH
Engineering Controls: Use well-ventilated area, local exhaust as needed
Personal Protective Equipment: Safety glasses or goggles, protective gloves (nitrile or neoprene), lab coat or impervious clothing for prolonged handling
Respiratory Protection: Not usually needed; use approved respirator for dusty conditions or if ventilation is poor
Hygiene Measures: Wash hands thoroughly after handling, do not eat or drink during use

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow viscous liquid
Odor: Mild, characteristic
Melting Point: Approximately −27°C
Boiling Point: Decomposes before boiling
Flash Point: 199°C (open cup)
Autoignition Temperature: >400°C
Solubility: Insoluble in water, soluble in organic solvents such as ethanol or oil
Partition Coefficient: log Kow ~12
Vapor Pressure: Very low at room temperature
Density: 0.950–0.969 g/cm³
pH: Not applicable (neutral oil)

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Decomposition Products: Thermal decomposition may yield carbon monoxide, carbon dioxide, acrid fumes
Reactivity: Unreactive under normal conditions
Incompatibility: Strong oxidizing or reducing agents, acids
Hazardous Polymerization: Will not occur

Toxicological Information

Acute Toxicity: Low acute oral and dermal toxicity (oral LD50 in rats > 10,000 mg/kg)
Chronic Toxicity: No evidence of chronic toxicity for workers at ordinary exposure; long-term safety established as dietary supplement
Eye/Skin Irritation: May produce mild irritation on sensitive individuals
Sensitization: Practically not sensitizing
Carcinogenicity: Not listed by IARC, NTP, OSHA, ACGIH
Mutagenicity and Reproductive Toxicity: No evidence found in animal studies
Other Effects: May interfere with vitamin K activity at pharmacological doses

Ecological Information

Ecotoxicity: No evidence of toxicity to aquatic life at environmental concentrations
Mobility: Expected to adsorb to soil and sediment due to low water solubility
Persistence and Degradability: Biodegradable under aerobic conditions
Bioaccumulation: Potential based on high octanol-water partition coefficient, but low environmental impact expected
Other Adverse Effects: No known harmful effects on ecosystems under normal use

Disposal Considerations

Disposal Methods: Dispose of in accordance with regional, national, and local environmental regulations; non-hazardous industrial waste
Container Disposal: Triple rinse before recycling or disposal, manage as controlled waste
Precautions: Do not release into environment or general waste streams, consult waste management authority for guidance

Transport Information

UN Number: Not regulated
Proper Shipping Name: Vitamin E Acetate
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions: Avoid spill, ship in line with local and international requirements

Regulatory Information

Safety, Health, and Environmental Regulations: Compliant with standards set by TSCA, REACH, DSL, and other national chemical inventories
OSHA Status: Not regulated as hazardous
Labeling Requirements: Product labeling follows GHS; no hazard pictogram required
SARA Title III: Not subject to reporting under Sections 302, 304, 313
California Proposition 65: Not listed
Other International Regulations: Meets EU cosmetic regulations, recognized as a GRAS food additive in the US