Material Safety Data Sheet (MSDS) – Vitamin A Acetate

1. Identification

Product Name: Vitamin A Acetate
Chemical Name: Retinol Acetate
CAS Number: 127-47-9
Synonyms: all-trans-Retinyl acetate
Manufacturer Information: Listed on packaging, consult supplier contact
Recommended Use: Dietary vitamin supplement, nutritional formulations
Emergency Phone: Local emergency response or poison control center

2. Hazard Identification

Classification: Reproductive toxicity (Category 1B); Acute Toxicity (Oral, Category 4); Specific target organ toxicity (repeated exposure, Category 2)
Pictogram: Health hazard, Exclamation mark
Signal Word: Danger
Hazard Statements: May damage the unborn child. Harmful if swallowed. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: Obtain special instructions before use. Avoid breathing dust. Wear protective gloves, eye protection. If exposed or concerned, get medical attention.
Routes of Exposure: Inhalation, ingestion, skin, and eyes
Acute Effects: Headache, nausea, drowsiness, skin itching

3. Composition / Information on Ingredients

Chemical Identity: Retinol Acetate
CAS Number: 127-47-9
Concentration: ≥ 95% by weight
Impurities and Stabilizing Additives: Information available on supplier’s certificate
Mixtures: Not applicable; pure compound

4. First Aid Measures

Inhalation: Remove to fresh air, keep person at rest, seek medical attention if symptoms occur
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical help if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice
Most Important Symptoms/Effects: Abdominal pain, nausea, headache, irritation, possible liver effects on repeated exposure
Medical Advice: Symptomatic treatment, observation for delayed effects

5. Fire-Fighting Measures

Flammability: Non-flammable solid, can emit toxic fumes in fire
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, water spray
Unsuitable Extinguishing Media: Do not use high-pressure water streams
Special Hazards: Carbon oxides, acetic acid vapor, irritating fumes
Protective Equipment: Positive pressure self-contained breathing apparatus, full protective suit
Advice for Firefighters: Avoid run-off water entering drains

6. Accidental Release Measures

Personal Precautions: Evacuate area, avoid dust formation, use personal protective equipment
Environmental Precautions: Prevent entry to watercourses, drains, soil
Methods for Cleanup: Sweep up and place in suitable container, avoid raising dust, ventilate area after cleanup
Disposal: Treat material as hazardous waste, follow local regulations

7. Handling and Storage

Precautions for Safe Handling: Avoid ingestion, inhalation, contact with skin or eyes, handle in well-ventilated place, do not eat, drink, or smoke while using
Fire/Explosion Protection: Keep away from ignition sources, discharge static electricity before handling
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated area, protected from light and incompatible substances
Incompatible Materials: Strong oxidizers, acids
Packing Materials: Container approved for food or pharmaceutical substances, impermeable to moisture and light

8. Exposure Controls and Personal Protection

Exposure Limits: No established OSHA or ACGIH limits; handle consistent with good laboratory practice
Engineering Controls: Local exhaust ventilation, eyewash station, safety shower
Personal Protection: Nitrile gloves, lab coat, safety glasses or goggles, dust mask if airborne concentration risk exists
Hygiene Measures: Wash hands before breaks and after handling, remove contaminated clothing
Monitoring: Regular workplace air monitoring in industrial settings

9. Physical and Chemical Properties

Appearance: Pale yellow to yellow, crystalline powder or oil
Odor: Mild, characteristic
Odor Threshold: Not established
pH: Not applicable
Melting Point/Freezing Point: 57-60°C
Boiling Point/Range: Decomposes before boiling
Flash Point: Not relevant (solid)
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible at room temperature
Solubility: Slightly soluble in water, freely soluble in ethanol, chloroform, ether, vegetable oils
Partition Coefficient (n-octanol/water): Log Kow 6.66 (estimated)
Decomposition Temperature: > 100°C
Viscosity: Not applicable
Density: Approximately 0.98 g/cm³

10. Stability and Reactivity

Chemical Stability: Stable under normal storage conditions (dark, cool, dry)
Reactivity: Not reactive under recommended handling
Hazardous Reactions: Reacts with strong oxidizers, acids producing toxic vapors
Conditions to Avoid: Light, heat, moisture, sources of ignition, air exposure
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, acetic acid fumes, possibly toxic particulate

11. Toxicological Information

Acute Toxicity: Oral LD50 (rat): 1514 mg/kg
Routes of Exposure: Inhalation, ingestion, skin absorption
Chronic Toxicity: May cause reproductive and developmental toxicity, possible liver damage after repeated high oral doses
Symptoms: Nausea, vomiting, blurred vision, skin irritation, fatigue
Sensitization: Not classified as skin sensitizer
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: Not classified as mutagenic
Reproductive Effects: Documented teratogenic and embryotoxic effects in animals

12. Ecological Information

Ecotoxicity: Harmful to aquatic organisms at high concentrations
Mobility in Soil: Expected to be immobile, binds strongly to soil
Persistence and Degradability: Slowly biodegradable, persistent in environment if not managed
Bioaccumulative Potential: Potential for bioaccumulation in aquatic species
Other Adverse Effects: May disrupt aquatic life cycles, no known effect on atmospheric ozone

13. Disposal Considerations

Waste Treatment Methods: Dispose of in accordance with local, regional, national, and international regulations
Contaminated Packaging: Handle like product waste, triple rinse containers before disposal
Landfill/Burning: Do not dispose of via general waste or incineration unless properly permitted
Special Precautions: Seek guidance from environmental authority, avoid environmental release

14. Transport Information

UN Number: Not regulated as dangerous goods for transport
Proper Shipping Name: Vitamin A Acetate
Transport Hazard Class: Non-hazardous
Packing Group: Not assigned
Environmental Hazards: No marine pollutant classification
Transport Precautions: Store secure, protect from moisture and sunlight, use sealed containers

15. Regulatory Information

TSCA Status: Listed
DSL (Canada): Listed
REACH (EU): Registered, subject to restrictions on certain uses
GHS Label Elements: Signal word “Danger”, hazard and precautionary statements as above
California Proposition 65: Not listed
SARA Title III: Not subject to reporting requirements under Section 302, 304, 313
Other Regulations: Compliance with national health and safety regulations for handling chemical substances