Material Safety Data Sheet for Isopropyl Acetate

Identification

Product Name: Isopropyl Acetate
CAS Number: 108-21-4
Synonyms: 1-Acetooxypropane, Isopropyl Ethanoate
Recommended Use: Solvent in coatings, adhesives, inks, and as an intermediate in organic synthesis
Manufacturer Information: Chemical manufacturers and large global distributors provide up-to-date contacts for emergencies and product safety information
Emergency Numbers: CHEMTREC, Poison Control, company-specific hotlines

Hazard Identification

Classification: Flammable liquid (Category 2), Eye irritation (Category 2A), Specific target organ toxicity - single exposure (Category 3)
Label Elements: Pictograms for flame and exclamation mark, warning signal word
Hazard Statements: Highly flammable liquid and vapor; causes serious eye irritation; may cause drowsiness or dizziness
Precautionary Statements: Keep away from sparks, heat, and open flames; use explosion-proof equipment; use only outdoors or in a well-ventilated area
Potential Health Effects: Vapors may cause headache, fatigue, and irritation; contact irritates skin and eyes
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
NFPA Ratings: Health - 1; Flammability - 3; Instability - 1

Composition / Information on Ingredients

Chemical Name: Isopropyl Acetate
CAS Number: 108-21-4
Concentration: 99% and above for pure product
Impurities/Additives: Trace moisture, residual acids, minor alcohol contaminants possible in technical grades
Molecular Formula: C5H10O2
Molecular Weight: 102.13 g/mol

First Aid Measures

Inhalation: Remove victim to fresh air immediately; seek medical attention for difficulty breathing or persistent symptoms
Skin Contact: Wash skin thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse eyes with water for at least 15 minutes, lifting upper and lower lids; consult a doctor
Ingestion: Do not induce vomiting; rinse mouth; get medical assistance if symptoms occur
Notes for Doctor: Treat symptomatically; consider risk of chemical pneumonitis if ingested

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical, alcohol-resistant foam, water spray for cooling containers
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, irritating aldehydes
Fire Hazards: Vapors form explosive mixtures with air; flashback possible; containers may rupture when heated
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear
Special Procedures: Cool fire-exposed tanks and cylinders with water spray; prevent run-off from entering drains

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate; eliminate ignition sources
Protective Equipment: Wear appropriate respirators, chemical-resistant gloves, eye protection
Spill Cleanup Methods: Contain spills with inert absorbent (e.g., sand, earth), collect residue in closable containers
Environmental Precautions: Stop leak if safe; prevent release to drains, soil, and waterways
Large Spill Response: Notify environmental authorities; remove sources of ignition

Handling and Storage

Handling: Work in well-ventilated areas; ground and bond containers; avoid breathing vapor; avoid contact with eyes, skin, clothing
Storage: Store in tightly closed containers in dry, cool, well-ventilated places, away from direct sunlight and incompatible chemicals
Incompatibilities: Strong oxidizers, acids, alkalis; avoid storage near ignition sources and reactive metals
Specific Procedures: Keep containers labeled; implement local exhaust if needed; provide spill containment

Exposure Controls and Personal Protection

Occupational Exposure Limits: OSHA PEL 250 ppm (TWA), ACGIH TLV 100 ppm (TWA) for isopropyl acetate
Engineering Controls: Use mechanical ventilation; fume hoods when feasible; prevent vapor concentrations above the recommended limits
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene); safety goggles or face shield; flame-resistant clothing; suitable respiratory protection under conditions of inadequate ventilation
Hygiene Practices: Wash hands after handling; remove contaminated clothing before eating or smoking

Physical and Chemical Properties

Appearance: Clear, colorless liquid
Odor: Fruity, sharp odor
Odor Threshold: Detectable at 7 ppm
Boiling Point: 89°C (192°F)
Melting Point: -73°C (-99°F)
Vapor Pressure: 25 mmHg at 20°C
Vapor Density: 3.5 (air = 1)
Solubility: Slightly soluble in water (3.1 g/100 mL at 20°C); freely soluble in most organic solvents
Flash Point: 2°C (36°F, closed cup)
Autoignition Temperature: 460°C
Evaporation Rate: 1.5 (butyl acetate = 1)
Partition Coefficient (log Kow): 1.3

Stability and Reactivity

Chemical Stability: Stable under recommended storage, normal handling
Hazardous Reactions: May form peroxides on extended exposure to air
Conditions to Avoid: Heat, sparks, open flames, strong oxidizing agents, acids, bases
Incompatible Materials: Potassium tert-butoxide, sodium hydroxide, chlorosulfonic acid, nitric acid
Hazardous Decomposition Products: Releases carbon monoxide, carbon dioxide, acetic acid under fire or thermal decomposition

Toxicological Information

Acute Toxicity: Oral LD50 (rat): 6750 mg/kg; Inhalation LC50 (rat): >16,000 ppm/4h; Dermal LD50 (rabbit): >9,400 mg/kg
Skin Corrosion/Irritation: Prolonged or repeated contact may cause irritation or dermatitis
Serious Eye Damage/Irritation: Vapors and liquid can cause moderate to severe irritation
Respiratory Effects: High vapor levels lead to dizziness, drowsiness, throat/airway irritation
Sensitization: Not known to cause skin or respiratory sensitization
Chronic Toxicity: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in available data
Target Organ Effects: Central nervous system depression in excessive exposure

Ecological Information

Environmental Fate: Volatile, may travel as vapor; partially degradable in air and soil under normal conditions
Acute Aquatic Toxicity: Low to moderate hazard to aquatic life; LC50 (fish, 96h): 320 mg/L (Oncorhynchus mykiss)
Persistence and Degradability: Readily biodegradable (OECD 301D test, >60% in 28 days)
Bioaccumulation: Low potential (log Kow 1.3)
Mobility in Soil: Likely to partition to air and leach into groundwater in large contamination events
Other Adverse Effects: No known significant effects or critical hazards beyond solvent impacts

Disposal Considerations

Waste Treatment Methods: Recycle or recover solvent where possible; incinerate at facilities approved for hazardous organic chemicals
Disposal of Product: Dispose of unused product as hazardous waste according to local, state, national regulations
Disposal of Contaminated Packaging: Rinse and send containers for recycling or disposal through licensed waste contractors
Sewage Disposal: Do not discharge to sewer without proper treatment and permits

Transport Information

UN Number: 1220
UN Proper Shipping Name: Isopropyl Acetate
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: II
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Secure containers upright; document hazmat shipping papers; provide emergency response information
Transport Labels: Flammable Liquid (red diamond)

Regulatory Information

OSHA: Classified hazardous under OSHA regulations for flammable, irritant properties
TSCA: Listed on the U.S. Toxic Substances Control Act Inventory
SARA Title III: Not subject to Section 302/304/313 reporting, but included in chemical inventory lists
REACH: Registered in the EU; Safety Data Sheets conform to REACH Annex II requirements
California Proposition 65: Isopropyl acetate does not appear on Prop 65 list of substances
Other International Regulations: Compliant with GHS/UN, Canadian WHMIS, Australian NICNAS, and Japanese CSCL inventory controls
Workplace Labeling: Proper chemical labels on all containers as required by local and national safety rules