Material Safety Data Sheet (MSDS) – Isobutyl Acetate

1. Identification

Product Name: Isobutyl Acetate
Chemical Formula: C6H12O2
Synonyms: Acetic acid, 2-methylpropyl ester; Isobutyl ethanoate
Recommended Uses: Solvent in coatings, inks, adhesives, extraction processes
Manufacturer Information: Contact details of the chemical supplier, emergency contact phone number
CAS Number: 110-19-0
UN Number: 1213
Relevant Identifiers: EINECS 203-745-1, RTECS ES5425000
Emergency Overview: Clear, flammable liquid with strong fruity odor often associated with lacquer and printing industries

2. Hazard Identification

Classification: Flammable liquid, irritant
GHS Label Elements: Flame, Exclamation Mark
Signal Word: Warning
Hazard Statements: H226 Flammable liquid and vapor; H319 Causes serious eye irritation; H335 May cause respiratory irritation
Precaution Statements: P210 Keep away from heat, sparks, open flames; P261 Avoid breathing vapor; P280 Wear protective gloves/eye protection
Other Hazards: Inhalation can cause headache, dizziness, drowsiness; skin contact may dry and crack skin with chronic exposure

3. Composition / Information on Ingredients

Chemical Name: Isobutyl Acetate
Percentage: ≥ 99% by weight
Impurities and Stabilizing Additives: Minor quantities of isobutanol, butyl acetate may be present
Physical Form: Liquid
Dangerous Components: No stabilizers typically used

4. First Aid Measures

Eye Contact: Rinse thoroughly with water for several minutes; lift eyelids and continue flushing; seek medical attention if irritation persists
Skin Contact: Wash exposed area with soap and water; remove contaminated clothing; consult a physician for persistent irritation
Inhalation: Remove person from the exposure area to fresh air; support breathing; call for medical help if symptoms like coughing or nausea continue
Ingestion: Rinse mouth with water; do not induce vomiting; get medical help immediately
Most Important Symptoms: Eye redness, tearing, headaches, nausea, confusion, feeling faint after excessive inhalation

5. Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, alcohol-resistant foam, carbon dioxide; avoid water jets
Unsuitable Extinguishing Media: Straight water streams may spread the fire
Specific Hazards: Vapors may form explosive mixtures with air; product floats and can be reignited
Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Special Procedures: Cool fire-exposed containers with water; evacuate downwind area
Combustion Products: Carbon monoxide, carbon dioxide, irritating fumes

6. Accidental Release Measures

Personal Precautions: Ventilate area of spill; keep people away; avoid breathing vapors
Protective Equipment: Chemical splash goggles, gloves, flame-resistant clothing, respirators for large spills
Environmental Precautions: Prevent entry into drains, sewers, or watercourses
Methods for Cleaning Up: Absorb with inert material such as sand or earth; place in sealed containers for that waste; wash down site after removal to prevent vapor buildup
Spill Response: Eliminate ignition sources; use spark-proof tools; control and contain leaks quickly

7. Handling and Storage

Safe Handling Advice: Handle in well-ventilated settings; ground all equipment; avoid direct contact; keep away from sources of heat and open flames
Precautions: Use non-sparking tools; prevent static build-up; follow standard safe work procedures
Storage Conditions: Store in tightly closed containers; keep in cool, dry, well-ventilated area; isolation from oxidizers; avoid temperatures above 40°C
Incompatible Materials: Avoid storage near acids, bases, strong oxidizing agents
Storage Class: Flammable liquids class

8. Exposure Controls and Personal Protection

Exposure Limits: ACGIH TLV 150 ppm (peak); OSHA PEL 150 ppm; NIOSH REL 150 ppm TWA
Engineering Controls: Use local exhaust ventilation at points of vapor release
Respiratory Protection: Use air-purifying respirators with organic vapor cartridges if exposure possible
Hand Protection: Nitrile or butyl rubber gloves
Eye Protection: Safety goggles or face shield
Skin Protection: Flame-resistant clothing, lab coats, chemical-resistant boots
Hygiene: Wash hands before eating and after handling; remove contaminated clothes and wash before reuse

9. Physical and Chemical Properties

Appearance: Colorless liquid
Odor: Fruity, strong aroma, often reminiscent of pears or cherries
Odor Threshold: 0.012 – 0.37 ppm
pH: Not applicable (non-aqueous)
Melting Point: -99°C
Boiling Point: 118°C
Flash Point: 22°C (closed cup)
Evaporation Rate: 1.2 (butyl acetate = 1)
Flammability: Highly flammable liquid
Explosion Limits: Lower - 1.3%, Upper - 7.5% (by volume in air)
Vapor Pressure: 10 mmHg at 20°C
Vapor Density: 4.0 (air = 1)
Relative Density: 0.868 g/cm³
Solubility: Slightly soluble in water; soluble in most organic solvents
Partition Coefficient (log Kow): 1.78
Auto-ignition Temperature: 421°C
Decomposition Temperature: Not specified
Viscosity: 0.7 mPa·s at 25°C

10. Stability and Reactivity

Reactivity: Reacts with strong oxidizing agents; may attack some plastics and rubbers
Chemical Stability: Stable under recommended storage and handling
Possibility of Hazardous Reactions: Forms explosive peroxides on contact with air over long period; vapors can ignite
Conditions to Avoid: Heat, flames, static discharge, direct sunlight
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, harmful gases if burned through incomplete combustion

11. Toxicological Information

Acute Toxicity: Oral LD50 (rat): 13,400 mg/kg; Inhalation LC50 (rat, 4h): > 6,370 ppm; Dermal LD50 (rabbit): > 17,400 mg/kg
Skin Corrosion/Irritation: Mild irritant, may cause dryness and cracking after prolonged or repeated exposure
Serious Eye Damage/Irritation: Causes transient irritation and redness
Respiratory or Skin Sensitization: Not expected to be a sensitizer
Germ Cell Mutagenicity: Not classified
Carcinogenicity: Not listed by IARC, ACGIH, NTP, or OSHA
Reproductive Toxicity: Studies do not indicate reproductive hazards under normal exposure
STOT - Single Exposure: May cause drowsiness, dizziness, headaches with inhalation
STOT - Repeated Exposure: High levels may affect central nervous system, liver over long term
Aspiration Hazard: Not classified

12. Ecological Information

Ecotoxicity: Moderately toxic to aquatic life; LC50 (fish, 96h): 96 mg/L; EC50 (daphnia, 48h): 83 mg/L
Persistence and Degradability: Readily biodegradable, breaks down within weeks in environment
Bioaccumulation: Low potential based on log Kow value
Mobility in Soil: Good mobility in soil, may leach into groundwater
Other Adverse Effects: No information on ozone depletion, photochemical ozone creation, endocrine disruption from this product

13. Disposal Considerations

Disposal Methods: Incinerate in chemical incinerator equipped with afterburner and scrubber; follow all federal, state, and local regulations
Container Disposal: Completely empty containers; flush with water; render unusable before recycling or disposal
Precautions: Keep material out of sewer or watercourses
Special Instructions: Consult licensed hazardous waste disposal contractor
Waste Classification: Classified as hazardous waste in most jurisdictions due to flammability

14. Transport Information

UN Number: 1213
UN Proper Shipping Name: Isobutyl Acetate
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Label: Flammable liquid
Marine Pollutant: No
Special Precautions for User: Use flame-proof equipment, cut electrical power if leak detected during transit
Transport in Bulk: According to Annex II of MARPOL 73/78 and IBC Code
Regulation: Follows IATA, IMDG, ADR guidelines
ERG Code: 128

15. Regulatory Information

OSHA Hazard Communication: Flammable liquid; irritant
TSCA Status: Listed on US TSCA Inventory
SARA Title III: Not listed as an extremely hazardous substance; not subject to Section 313
California Prop 65: Not listed
Canadian WHMIS Classification: B2 (Flammable liquid), D2B (Other toxic effects, skin/eye irritant)
European Directives: Classified as dangerous; Symbol: F (flammable), Xi (irritant)
REACH Status: Registered substance
Chemical Control Laws: Meets criteria in Australia AICS, Japan ENCS, China IECSC, Philippines PICCS, New Zealand NZIoC