Material Safety Data Sheet (MSDS) for Diacetin

Identification

Product Name: Diacetin
Synonyms: Glycerol diacetate, 1,2-Diacetin, Glycerin diacetate
Chemical Formula: C7H12O5
CAS Number: 25395-31-7
Intended Use: Plasticizer, solvent, flavoring agent
Supplier Details: Contact manufacturer or distributor for company name, address, phone number, and emergency phone information
Recommended Restrictions: Industrial and professional use only, avoid food or pharmaceutical applications unless certified

Hazard Identification

GHS Classification: Not classified as hazardous as per current regulations
Label Elements: No pictogram required
Signal Word: None
Hazard Statements: May cause mild skin or eye irritation
Precautionary Statements: Avoid contact with skin and eyes, wash hands after handling, use in well-ventilated area
Other Hazards: Spilled material can create slipping hazard

Composition / Information on Ingredients

Chemical Name: Glycerol diacetate (Diacetin)
Concentration: Typically >98% pure
Impurities: Trace amounts of monoacetin and triacetin possible
Additives: None if unformulated

First Aid Measures

General Advice: Move affected person away from exposure source
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and soap
Eye Contact: Rinse cautiously with water for at least 15 minutes, seek medical attention if irritation persists
Inhalation: Move to fresh air, keep at rest, consult a physician if symptoms develop
Ingestion: Rinse mouth with water, do not induce vomiting, get medical help if large amounts are ingested
Symptoms/Effects: Minor skin reddening, eye watering, throat discomfort if inhaled in mist form

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, carbon dioxide, or dry powder
Unusual Fire Hazards: Product can form combustible mixtures at elevated temperatures
Combustion Products: Produces carbon oxides and acetic acid fumes
Protective Equipment: Wear full protective suit and self-contained breathing apparatus
Explosion Data: No data available on sensitivity to mechanical impact or static discharge
Firefighting Instructions: Use water spray to cool containers exposed to fire

Accidental Release Measures

Personal Precautions: Wear safety goggles, gloves, and protective clothing
Environmental Precautions: Prevent run-off into sewers and waterways
Containment: Stop leak if safe to do so, dike area with inert material (sand, earth)
Cleanup Procedures: Soak up with absorbent material, transfer to suitable container for disposal, clean spill area with water

Handling and Storage

Handling: Handle in a well-ventilated space, avoid inhaling vapors or mist, wash hands before eating or drinking, avoid contact with skin and eyes
Storage: Store in tightly closed original container in cool, dry, well-ventilated area, keep away from heat, sparks, and open flames, keep separate from incompatible substances such as strong oxidizers or acids
Incompatibilities: Strong acids, strong bases, oxidizing agents
Other Precautions: Prevent static discharge, use proper grounding procedures

Exposure Controls and Personal Protection

Engineering Controls: Provide local exhaust ventilation to minimize exposure
Exposure Limits: No specific occupational exposure limits established for Diacetin
Personal Protective Equipment:

  • Eye Protection: Safety goggles or face shield
  • Skin Protection: Chemical-resistant gloves and lab coat
  • Respiratory Protection: Use approved respirator if ventilation is inadequate
  • Hygiene Measures: Remove contaminated clothing and wash before reuse, wash thoroughly after handling

Physical and Chemical Properties

Form: Oily liquid
Color: Colorless to pale yellow
Odor: Mild, sweet, slightly acetic
Boiling Point: 258°C
Melting Point: -35°C
Flash Point: 185°C (closed cup)
Density: 1.17 g/cm3 at 20°C
Solubility: Soluble in water and ethanol
Vapor Pressure: <0.01 mmHg at 20°C
Viscosity: Moderate (5-10 cP at 25°C)
Partition Coefficient: log Pow < 0.5
pH: Neutral (6-7) in aqueous solution

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Possible Reactions: Hydrolysis may happen in presence of strong acid or base, releasing acetic acid and glycerol
Conditions to Avoid: Excess heat, direct sunlight, moisture infiltration
Incompatible Materials: Strong acids, alkalis, oxidizing agents
Decomposition Products: Acetic acid and carbon oxides under fire conditions

Toxicological Information

Acute Toxicity: Low toxicity, LD50 (oral, rat) > 5,000 mg/kg
Skin Corrosion/Irritation: Mild irritant to skin on prolonged contact
Serious Eye Damage/Irritation: Mild but reversible irritation
Respiratory Effects: Inhalation of mist may cause mild respiratory tract irritation
Chronic Toxicity: No evidence of carcinogenic, mutagenic, or reproductive effects in available data
Sensitization: No known sensitizing effects
Additional Information: Not classified as a reproductive or developmental toxin, limited animal data shows low hazard

Ecological Information

Aquatic Toxicity: Not expected to be harmful to aquatic life, biodegradable
Persistence/Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Low, due to high solubility in water
Mobility in Soil: Likely to leach if released in large quantities
Other Effects: No known significant environmental impact or critical hazards

Disposal Considerations

Waste Disposal: Dispose according to local, regional, and national regulations for non-hazardous liquid waste
Contaminated Packaging: Triple rinse and offer clean containers for recycling or reconditioning, otherwise dispose as chemical waste
Special Instructions: Do not allow material to enter surface water or drains in bulk

Transport Information

UN Number: Not regulated for transport
Proper Shipping Name: Not dangerous goods
Transport Hazard Class: Not classified
Packing Group: Not applicable
Special Precautions: Prevent container damage and leaks during transit; maintain upright position and careful handling

Regulatory Information

Inventory Listings: Listed on TSCA (US), REACH (EU), DSL (Canada), AICS (Australia)
Labeling Requirements: Not regulated by OSHA Hazard Communication Standard
Other Regulatory Info: Not subject to SARA Title III, CERCLA, PRI, or California Proposition 65; European CLP: Not classified as dangerous
Workplace Controls: Recommend compliance with general industrial hygiene practices and any additional requirements specific to site operations